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KMID : 0043319990220040391
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Archives of Pharmacal Research
1999 Volume.22 No. 4 p.391 ~ p.397
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Synthesis and In Vitro Antibacterial Activity of C-3’ Pyridinium Cephalosporin Derivatives
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Chung In-Hwa
Kim Choong-Sup
Seo Jae-Hong
Chung Bong-Young
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Abstract
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The quaternary ammonium cephalosporin derivatives were prepared with various pyridines substituted at the 3 or/and 4 position. Their in vitro antibacterial activities were determined and substituent effect on pyridine nucleus was studied. Preparation of substituted pyridines are also described.
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KEYWORD
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Quaternary pyridinium cephalosporin derivatives, Antibacterial activity
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